Steroids side effects are linked to brain weakening.


Steroids side effects

Steroids side effects are known; however, the use of this type of medicines increases every year. According to a recent study, the use of oral or inhaled glucocorticoids, a class of steroids used to treat asthma and other inflammatory diseases by reducing inflammation, may cause harmful alterations in the brain’s white matter.

Common steroids side effects

Steroids Side Effects

The dosage, kind of steroid, and time of treatment all affect the likelihood of steroids side effects. There are more severe side effects than others. Systemic steroids side effects frequently include:

  • Mood swings.
  • Hazy vision.
  • Swollen, “puffy” face.
  • Difficulty sleeping.
  • Easy bruising.
  • Enhanced appetite.
  • Weight increase.
  • Muscle weakness.
  • The onset of, or deteriorating of, diabetes.
  • Nervousness, restlessness.
  • Increased growth of body hair.
  • Lower resistance to infection.
  • Acne.
  • Osteoporosis (bone destabilizing disease).
  • The onset of, or deterioration of, hypertension.
  • Stomach irritation.
  • Cataracts and glaucoma.
  • Water retention.

Steroids aftermath on the brain

This study, led by Merel van der Meulen, a postdoctoral fellow at Leiden University Medical Center in the Netherlands, and published in the journal BMJ Open,” shows that both systemic and inhaled glucocorticoids are associated with an apparently widespread reduction in white matter integrity.”

The tissue known as “white matter” is what connects brain cells to the rest of the nervous system. The brain’s capacity to process information, focus on objects, and recollection can be slowed by having less white matter. Lower white matter volumes are also linked to psychiatric conditions like anxiety, depression, and irritability.

Thomas Ritz, a psychology professor at Southern Methodist University who has studied the effects of steroids on people with asthma, said that the new study is particularly intriguing because it demonstrates how medication use affects white matter, which is necessary for neurons to connect with one another. He wasn’t a part of the research.

But according to neuroimmunologist Dr. Avindra Nath, clinical director of the National Institute of Neurological Disorders and Stroke, who was also not involved in the study, “there’s no reason for panic,” The brain does shrink when patients are given steroids. Still, it returns when the steroids are stopped, doctors have long known, according to Nath.

These “may be transient impacts,” he said, referring to the brain’s capacity to restructure its connections, functions, and structure. They don’t have to be permanent, necessarily. White matter can heal itself.”

Extensive use and possible steroids side effects

side effects from corticosteroids

Due to their widespread use in a variety of illnesses, specialists suggest that glucocorticoids are among the most often prescribed anti-inflammatory drugs.

Allergies, chronic obstructive pulmonary disease (COPD), Crohn’s disease and other forms of inflammatory bowel disease, eczema, and other skin conditions, lupus, tendinitis, multiple sclerosis, osteoarthritis, and rheumatoid arthritis can all be treated with oral and inhaled glucocorticoids in addition to treating asthma.

However, quick-relief inhalers used to stop an asthma attack should not be confused with glucocorticoid inhalers. Albuterol, levalbuterol, and pirbuterol are examples of non-steroid drugs found in quick-relief inhalers that relax the lungs’ muscles and can quickly open airways. Inhaled corticosteroids are indicated for the longer-term management of inflammatory diseases; they are ineffective in crises.

Prior studies have connected long-term oral glucocorticoid use to structural abnormalities in the brain, atrophy of certain brain regions, and mental health conditions such as anxiety, depression, confusion, and disorientation. Additionally, research has shown that asthma sufferers are more likely than non-asthmatics to experience cognitive and memory decline in later life as a result of steroids side effects.

However, many earlier studies have been limited in scope and occasionally inconclusive, according to specialists.

The study revealed the link between glucocorticoid consumption and mental health.

The UK BioBank, a sizable biological research facility that tracked 500,000 UK citizens from 2006 to 2010, provided the data for the current study. The researchers identified 222 oral glucocorticoid users and 557 inhaled glucocorticoid users in that database who had never been diagnosed with a neurological, hormonal, or mental health condition.

These individuals had evaluations of their cognitive and mental health as well as a diffusion MRI of the brain. Researchers took that information and compared it to the cognitive and MRI results of over 24,000 non-steroid users in the database.

According to the study’s authors, this is the largest study examining the relationship between glucocorticoid use and brain anatomy. It is also the first to look into these relationships in people who use inhaled glucocorticoids.

Anxiety Disorder

Inhalers made the least difference

The study discovered that those who consistently use oral steroids for extended periods of time have the most severe white matter damage. Chronic oral steroid users were evaluated slower in terms of mental processing speed than non-users. Additionally, apathy, despair, weariness, and restlessness were more common among oral steroid users than non-users.

The study discovered that inhaling steroids had the slightest effect on white matter.

According to pulmonologist Dr. Raj Dasgupta, an assistant professor of clinical medicine at the Keck School of Medicine at the University of Southern California, it is consistent with what medical professionals observe in clinical practice. He wasn’t a part of the investigation.

inhaled corticosteroids

He said that the inhaled form of glucocorticoids didn’t cause negative effects as frequently. Of course, avoiding triggers and changing one’s lifestyle will always be the cornerstones of treatment for allergies and asthma.

According to Dasgupta, due to the numerous adverse effects of steroid use that can also affect health, particularly brain health, pulmonologist and rheumatologists are cautious about prescribing the smallest dose of steroids required to control symptoms.

“As a physician, you start thinking about how to properly and quickly wean a patient off of these medications as soon as you start them on them. According to Dasgupta, steroids can cause weight gain, which increases the risk of developing diabetes and high blood pressure.

He continued, “When you give steroids to diabetics, their blood sugar can go up. “When you use steroids acutely, you may experience sleeplessness and sleep problems, and because they depress the immune system, long-term steroid use puts you at a significant risk for infections.”

More study is required on glucocorticoids aftereffect.

The new study was constrained. For starters, Ritz said, it was unable to calculate the dosage of steroids or monitor adherence.

According to Ritz, “possible overreporting of intake is also a problem. We know that only 50% of asthma patients take their medication as directed. “You should take your inhaled corticosteroids as frequently as possible, albeit at the lowest dose that enables you to control your asthma. They work locally to reduce inflammation.

This study provides us with another more reason to maintain low dosages, he continued.

The inability to distinguish between users of infusions and theose who use steroid tablets is another drawback, according to the study’s authors.


As long as you do not have severe asthma, the study essentially validates what we have known for a long time about managing asthma: Use as few systemic (oral) corticosteroids as feasible. Stick to inhaled steroids and talk with your doctor about how you’ll reduce your medicine dosages when things are going well, Ritz said.

Nath remarked, “It’s a pretty nicely done study. However, the results call for additional research to be conducted to determine how long these steroids side effects continue and how they can be reversed.

Avoid the use of steroids and prevent unwanted effects from glucocorticoids.

In many cases, the use of steroids is not a medical necessity. You can avoid steroid therapy, switching to natural and holistic remedies. Medical techniques, such as acupuncture, Ayurveda, and homeopathy may help you to avoid the consumption of steroids and thus prevent steroids side effects.

Make sure you understand the previous sentences correctly. It is not you who may decide to take steroids or not. Consult your physician and ask if there are any chances to reduce the dose of steroids or stop taking them to prevent steroids side effects. Your medical condition may require steroids therapy, and in this case, the positive result from using glucocorticoids may be more important than any possible steroid side effects that may develop.

If you live in the City of Brotherly Love, contact Philadelphia Holistic Clinic, and book your appointment with Dr. Victor Tsan for evaluation and treatment.

At the clinic, you will receive all necessary holistic tests and treatments provided by licensed medical professionals.

In many cases, using acupuncture and homeopathic remedies, we will be able to reduce the dose of steroids that you regularly consume or help you to avoid the consumption of them.

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